{"id":5425,"date":"2026-03-13T13:55:47","date_gmt":"2026-03-13T13:55:47","guid":{"rendered":"https:\/\/airna.com\/news\/job-post\/director-head-of-bioinformatics\/"},"modified":"2026-03-13T14:12:21","modified_gmt":"2026-03-13T14:12:21","slug":"director-head-of-bioinformatics","status":"publish","type":"job-post","link":"https:\/\/airna.com\/de\/news\/job-post\/director-head-of-bioinformatics\/","title":{"rendered":"Director, Head of Bioinformatics"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\"><strong>COMPANY OVERVIEW<\/strong><\/h3>\n\n<p>AIRNA is a biotechnology company with a mission to be the leading RNA editing company delivering precision therapies to patients with rare and common diseases.<\/p>\n\n<p>AIRNA is harnessing advances in genetics to develop transformative RNA-editing medicines that improve human health. Our proprietary platform is based on groundbreaking research by pioneers of the field and company co-founders Thorsten Stafforst (University of T\u00fcbingen) and Jin Billy Li (Stanford University) and enables optimal potency, safety, and delivery. AIRNA is advancing a robust pipeline of therapeutic candidates that are designed to provide functional cures for severe or chronic diseases by repairing harmful genetic variants or introducing beneficial variants promote optimal health.<\/p>\n\n<p>AIRNA has raised $245 million in financing from a world-class syndicate of investors including Arch Venture Partners, Forbion, Venrock Healthcare Capital Partners, RTW Investments, Nextech Invest, and ND Capital. We value teamwork, resilience, excellence, human, and health, and have a diverse team at both our headquarters in Cambridge, MA and our research operations in T\u00fcbingen, Germany. <\/p>\n\n<h3 class=\"wp-block-heading\"><strong>POSITION SUMMARY<\/strong><\/h3>\n\n<p>The Head of Bioinformatics will lead the strategic vision, build and manage a high-performing computational biology team, and drive data science innovation across discovery, preclinical, and clinical development programs. This leader will play a critical role in advancing our RNA editing platform by developing robust computational frameworks for guide design, off-target prediction, transcriptome-wide analyses, biomarker development, and clinical data integration. <\/p>\n\n<p>The ideal candidate combines deep expertise in genomics and RNA biology with demonstrated leadership experience in biotech or pharmaceutical environments, ranging from early discovery to clinical-stage activities.<\/p>\n\n<h3 class=\"wp-block-heading\"><strong>RESPONSIBILTIES<\/strong><\/h3>\n\n<p><strong><u><span style=\"text-decoration: underline;\">Scientific &amp; Technical Leadership<\/span><\/u><\/strong><\/p>\n\n<ul class=\"wp-block-list\">\n<li>Define and execute the bioinformatics strategy aligned with company objectives and clinical milestones.<\/li>\n\n\n\n<li>Mine large public domain databases to build innovative analysis strategies to generate focused hypotheses for the identification of new therapeutic targets.<\/li>\n\n\n\n<li>Apply advanced analytics to large-scale Genome-Wide Association Studies (GWAS) and mutation datasets and interpret genomic information for a variety of Cardiovascular, Thrombotic and Metabolic or Rare genetic diseases.<\/li>\n\n\n\n<li>Combine molecular biology and epidemiology expertise with data analysis strategies to identify novel gain of function variants.<\/li>\n\n\n\n<li>Establish machine learning approaches to improve editing efficiency prediction and specificity modeling.\n<ul class=\"wp-block-list\">\n<li>Build AI based data analysis strategies to identify chemical modification patterns required for efficient endogenous ADAR based RNA editing.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Lead development of computational tools and pipelines for:\n<ul class=\"wp-block-list\">\n<li>RNA editing guide design and optimization<\/li>\n\n\n\n<li>Transcriptome-wide off-target assessment<\/li>\n\n\n\n<li>RNA-seq, single-cell RNA-seq, long-read sequencing analysis<\/li>\n\n\n\n<li>Variant detection and editing quantification<\/li>\n\n\n\n<li>Biomarker discovery and patient stratification<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Oversee analysis of preclinical and clinical sequencing datasets (GLP\/GCP compliant environments).<\/li>\n\n\n\n<li>Integrate multi-omics datasets to support translational and clinical strategy.<\/li>\n\n\n\n<li>Use data analysis, visualization, storytelling, and data technologies to scope, define and deliver AI-based solutions.<\/li>\n<\/ul>\n\n<p><strong>Clinical &amp; Translational Support<\/strong><\/p>\n\n<ul class=\"wp-block-list\">\n<li>Partner with Clinical Development to support trial design, endpoint strategy, and regulatory submissions.<\/li>\n\n\n\n<li>Lead bioinformatics contributions to IND\/CTA filings and interactions with regulatory agencies.<\/li>\n\n\n\n<li>Develop and maintain reproducible, auditable pipelines suitable for clinical data reporting.<\/li>\n<\/ul>\n\n<p><strong>Team Leadership &amp; Cross-Functional Collaboration<\/strong><\/p>\n\n<ul class=\"wp-block-list\">\n<li>Build, mentor, and scale a high-performing bioinformatics and computational biology team.<\/li>\n\n\n\n<li>Collaborate cross-functionally with Discovery, Preclinical, Translational Medicine, CMC, Regulatory, and Clinical Operations.<\/li>\n\n\n\n<li>Drive a culture of rigor, reproducibility, and data integrity.<\/li>\n\n\n\n<li>Publish and present findings in peer-reviewed journals and scientific conferences.<\/li>\n\n\n\n<li>Prepare written and oral reports on a regular basis.<\/li>\n\n\n\n<li>Maintain clear and accurate communication with supervisor, team members, and collaborators.<\/li>\n<\/ul>\n\n<p><strong>Support for Infrastructure &amp; Data Strategy<\/strong><\/p>\n\n<ul class=\"wp-block-list\">\n<li>Collaborate with head of IT for scalable cloud-based data infrastructure and secure data governance frameworks to support bioinformatics.<\/li>\n\n\n\n<li>Oversee implementation of workflow management systems and version-controlled analysis pipelines.<\/li>\n\n\n\n<li>Ensure bioinformatics group compliance with data privacy and regulatory standards in collaboration with IT and other stakeholders (e.g., HIPAA, GDPR as applicable).<\/li>\n<\/ul>\n\n<h3 class=\"wp-block-heading\"><strong>REQUIREMENTS<\/strong><\/h3>\n\n<ul class=\"wp-block-list\">\n<li>Ph.D. in Bioinformatics, Computational Biology, Genomics, Systems Biology, or related field.<\/li>\n\n\n\n<li>10+ years of experience in biotech or pharma, with increasing leadership responsibility.<\/li>\n\n\n\n<li>Demonstrated expertise in RNA biology, transcriptomics, and NGS data analysis.<\/li>\n\n\n\n<li>Experience supporting clinical-stage programs and regulatory submissions.<\/li>\n\n\n\n<li>Strong programming skills (Python, R) and experience with workflow tools (Nextflow, Snakemake, WDL\/Cromwell).<\/li>\n\n\n\n<li>Background in machine learning applied to genomics.<\/li>\n\n\n\n<li>Experience with cloud platforms (AWS, GCP, or Azure).<\/li>\n\n\n\n<li>Proven track record of building and leading high-performing teams.<\/li>\n\n\n\n<li>Familiarity with models &amp; AI products applied to a broad range of business use cases related to research and development.<\/li>\n\n\n\n<li>Innovative and critical thinking, problem solving, cross-disciplinary communications<\/li>\n<\/ul>\n\n<p><strong>Preferred<\/strong><\/p>\n\n<ul class=\"wp-block-list\">\n<li>Experience in RNA therapeutics, gene editing, or nucleic acid drug development.<\/li>\n\n\n\n<li>Familiarity with ADAR-mediated RNA editing mechanisms.<\/li>\n\n\n\n<li>Experience with long-read sequencing technologies (PacBio, Oxford Nanopore).<\/li>\n<\/ul>\n\n<p><strong>Key Competencies<\/strong><\/p>\n\n<ul class=\"wp-block-list\">\n<li>Strategic thinking with hands-on scientific depth<\/li>\n\n\n\n<li>Strong executive communication skills<\/li>\n\n\n\n<li>Regulatory and compliance awareness<\/li>\n\n\n\n<li>Collaborative leadership style<\/li>\n\n\n\n<li>Results-oriented with high scientific rigor<\/li>\n<\/ul>\n\n<h3 class=\"wp-block-heading\"><strong>What We Offer<\/strong><\/h3>\n\n<ul class=\"wp-block-list\">\n<li>Opportunity to shape the future of RNA editing therapeutics<\/li>\n\n\n\n<li>Competitive compensation, equity participation, and benefits\n<ul class=\"wp-block-list\">\n<li>Salary Range: $220,000 &#8211; $260,000<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Collaborative and mission-driven culture<\/li>\n<\/ul>\n\n<h3 class=\"wp-block-heading\"><strong>LOCATION<\/strong><\/h3>\n\n<p>AIRNA has a hybrid work model, and the role will be based in AIRNA\u2019s corporate headquarters in Cambridge, MA ~3 days per week.<\/p>\n\n<p><\/p>\n\n<p>To apply for for this position, please send your cover letter and CV to <a href=\"mailto:careers@airna.com\">careers@airna.com<\/a>.<\/p>\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Head of Bioinformatics will lead the strategic vision, build and manage a high-performing computational biology team, and drive data science innovation across discovery, preclinical, and clinical development programs.<\/p>\n","protected":false},"template":"","job-location":[53],"class_list":["post-5425","job-post","type-job-post","status-publish","hentry","job-location-united-states-de"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Director, Head of Bioinformatics &#8212; Airna<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Director, Head of Bioinformatics &#8212; Airna\" \/>\n<meta property=\"og:description\" content=\"The Head of Bioinformatics will lead the strategic vision, build and manage a high-performing computational biology team, and drive data science innovation across discovery, preclinical, and clinical development programs.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/airna.com\/de\/news\/job-post\/director-head-of-bioinformatics\/\" \/>\n<meta property=\"og:site_name\" content=\"Airna\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-13T14:12:21+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"4\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/airna.com\/de\/news\/job-post\/director-head-of-bioinformatics\/\",\"url\":\"https:\/\/airna.com\/de\/news\/job-post\/director-head-of-bioinformatics\/\",\"name\":\"Director, Head of Bioinformatics &#8212; Airna\",\"isPartOf\":{\"@id\":\"https:\/\/airna.com\/de\/#website\"},\"datePublished\":\"2026-03-13T13:55:47+00:00\",\"dateModified\":\"2026-03-13T14:12:21+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/airna.com\/de\/news\/job-post\/director-head-of-bioinformatics\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/airna.com\/de\/news\/job-post\/director-head-of-bioinformatics\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/airna.com\/de\/news\/job-post\/director-head-of-bioinformatics\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/airna.com\/de\/home\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Director, Head of Bioinformatics\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/airna.com\/de\/#website\",\"url\":\"https:\/\/airna.com\/de\/\",\"name\":\"Airna\",\"description\":\"TRANSFORMING LIVES, ONE RNA EDIT AT A TIME\",\"publisher\":{\"@id\":\"https:\/\/airna.com\/de\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/airna.com\/de\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/airna.com\/de\/#organization\",\"name\":\"Airna\",\"url\":\"https:\/\/airna.com\/de\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/airna.com\/de\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/airna.com\/wp-content\/uploads\/2025\/03\/AIRNA-logo.png\",\"contentUrl\":\"https:\/\/airna.com\/wp-content\/uploads\/2025\/03\/AIRNA-logo.png\",\"width\":280,\"height\":81,\"caption\":\"Airna\"},\"image\":{\"@id\":\"https:\/\/airna.com\/de\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.linkedin.com\/company\/airna-bio\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Director, Head of Bioinformatics &#8212; Airna","robots":{"index":"noindex","follow":"follow"},"og_locale":"de_DE","og_type":"article","og_title":"Director, Head of Bioinformatics &#8212; Airna","og_description":"The Head of Bioinformatics will lead the strategic vision, build and manage a high-performing computational biology team, and drive data science innovation across discovery, preclinical, and clinical development programs.","og_url":"https:\/\/airna.com\/de\/news\/job-post\/director-head-of-bioinformatics\/","og_site_name":"Airna","article_modified_time":"2026-03-13T14:12:21+00:00","twitter_card":"summary_large_image","twitter_misc":{"Gesch\u00e4tzte Lesezeit":"4\u00a0Minuten"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/airna.com\/de\/news\/job-post\/director-head-of-bioinformatics\/","url":"https:\/\/airna.com\/de\/news\/job-post\/director-head-of-bioinformatics\/","name":"Director, Head of Bioinformatics &#8212; Airna","isPartOf":{"@id":"https:\/\/airna.com\/de\/#website"},"datePublished":"2026-03-13T13:55:47+00:00","dateModified":"2026-03-13T14:12:21+00:00","breadcrumb":{"@id":"https:\/\/airna.com\/de\/news\/job-post\/director-head-of-bioinformatics\/#breadcrumb"},"inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/airna.com\/de\/news\/job-post\/director-head-of-bioinformatics\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/airna.com\/de\/news\/job-post\/director-head-of-bioinformatics\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/airna.com\/de\/home\/"},{"@type":"ListItem","position":2,"name":"Director, Head of Bioinformatics"}]},{"@type":"WebSite","@id":"https:\/\/airna.com\/de\/#website","url":"https:\/\/airna.com\/de\/","name":"Airna","description":"TRANSFORMING LIVES, ONE RNA EDIT AT A TIME","publisher":{"@id":"https:\/\/airna.com\/de\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/airna.com\/de\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"de"},{"@type":"Organization","@id":"https:\/\/airna.com\/de\/#organization","name":"Airna","url":"https:\/\/airna.com\/de\/","logo":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/airna.com\/de\/#\/schema\/logo\/image\/","url":"https:\/\/airna.com\/wp-content\/uploads\/2025\/03\/AIRNA-logo.png","contentUrl":"https:\/\/airna.com\/wp-content\/uploads\/2025\/03\/AIRNA-logo.png","width":280,"height":81,"caption":"Airna"},"image":{"@id":"https:\/\/airna.com\/de\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.linkedin.com\/company\/airna-bio"]}]}},"_links":{"self":[{"href":"https:\/\/airna.com\/de\/wp-json\/wp\/v2\/job-post\/5425","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/airna.com\/de\/wp-json\/wp\/v2\/job-post"}],"about":[{"href":"https:\/\/airna.com\/de\/wp-json\/wp\/v2\/types\/job-post"}],"wp:attachment":[{"href":"https:\/\/airna.com\/de\/wp-json\/wp\/v2\/media?parent=5425"}],"wp:term":[{"taxonomy":"job-location","embeddable":true,"href":"https:\/\/airna.com\/de\/wp-json\/wp\/v2\/job-location?post=5425"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}