Location

Cambridge, MA
United States

Senior Scientist, Toxicology

COMPANY OVERVIEW

AIRNA is a biotechnology company with a mission to be the leading RNA editing company delivering precision therapies to patients with rare and common diseases.

AIRNA is harnessing advances in genetics to develop transformative RNA-editing medicines that improve human health. Our proprietary platform is based on groundbreaking research by pioneers of the field and company co-founders Thorsten Stafforst (University of Tübingen) and Jin Billy Li (Stanford University) and enables optimal potency, safety, and delivery. AIRNA is advancing a robust pipeline of therapeutic candidates that are designed to provide functional cures for severe or chronic diseases by repairing harmful genetic variants or introducing beneficial variants promote optimal health.

AIRNA has received $245 million in financing from a world-class syndicate of investors including Arch Venture Partners, Forbion, Venrock Healthcare Capital Partners, RTW Investments, Nextech Invest, and ND Capital. We value teamwork, resilience, excellence, human, and health, and have a diverse team at both our headquarters in Cambridge, MA and our research operations in Tübingen, Germany.

JOB DESCRIPTION

AIRNA is looking for a highly motivated and passionate Senior Scientist (Toxicology) to support pre-clinical safety/Toxicology for successful development of the company’s lead molecules. Reporting to the Director of DMPK and Clinical Pharmacology, this position will provide a wide range of scientific expertise associated with Toxicology and Safety Pharmacology for R&D Project Teams. The successful candidate will play a critical role in designing, conducting, and interpreting toxicology studies, ensuring regulatory compliance, and contributing to risk assessments of AIRNA clinical programs.

This position is based in Cambridge MA.

RESPONSIBILITIES

  • Design, oversee, and interpret toxicology studies, including in vitro and in vivo assessments.
  • Provide expert guidance on toxicology and safety-related issues to internal teams and external stakeholders.
  • Prepare and review toxicology study reports, risk assessments, and regulatory documents (e.g., IND, CTA, NDA, FDA submissions).
  • Collaborate with multidisciplinary teams, including regulatory, clinical, and R&D groups, to ensure compliance with industry and regulatory standards.
  • Keep up to date with emerging toxicology trends, regulatory guidelines, and scientific advancements.
  • Represent the company at scientific meetings, conferences, and regulatory discussions. Mentor pre-clinical team scientist and contribute to the development of toxicology best practices.

QUALIFICATIONS

  • PhD in toxicology, pharmacology or related disciplines with a minimum of 5+yrs of relevant industry experience.
  • BS/MS degree and DABT with 10 years of relevant experience.
  • Demonstrated drug development in non-clinical toxicology, including study design, study protocol development and study execution. Experienced antisense oligonucleotides or siRNA is desirable.
  • Knowledgeable about GLP policies and/or regulatory nonclinical testing requirements for pharmaceutical development.
  • In depth familiarity with ICH, FDA and other regulatory guidance and regulations relevant to nonclinical research.
  • Team-player, excellent written and oral communication, interpersonal, and organizational skills.

To apply for for this position, please send your cover letter and CV to [email protected].

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